Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

The recent development of a CRISPR-Cas9-based homing system for the suppression of
Anopheles gambiae is encouraging; however, with current designs, the slow emergence of …

The use of a site-specific homing-based gene drive for insect pest control has long been
discussed, but the easy design of such systems has become possible only with the recent …

Proposed genetic approaches for reducing human malaria include population modification,
which introduces genes into vector mosquitoes to reduce or prevent parasite transmission. …

The sterile insect technique (SIT) is an environmentally safe and proven technology to
suppress wild populations. To further advance its utility, a novel CRISPR-based technology …

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow
fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. …

… b, c We detected different outputs for both yellow and white loci when the tGD chromosome
was inherited from the mother. b Cas9 cut (red bar) seems to occur at the zygote stage for the …

MGDrivE: A modular simulation framework for the spread of gene drives through spatially
explicit mosquito populations - Sánchez C. - 2020 - Methods in Ecology and Evolution - Wiley …

Malaria is among the world’s deadliest diseases, predominantly affecting Sub-Saharan
Africa and killing over half a million people annually. Controlling the principal vector, the …

Cas9/guide RNA (gRNA)‐based gene drive systems are expected to play a transformative
role in malaria elimination efforts., whether through population modification, in which the drive …