Over the last two decades, the mutation of mitochondrial DNA (mtDNA) has emerged as a
major cause of inherited human disease. The disorders present clinically in at least 1 in 10 …

Mitochondrial DNA (mtDNA) mutations are a major cause of genetic disease, but their
prevalence in the general population is not known. We determined the frequency of ten …

Epigenetics encapsulates a group of molecular mechanisms including DNA methylation,
histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk …

Background Indian Asians, who make up a quarter of the world's population, are at high risk
of developing type 2 diabetes. We investigated whether DNA methylation is associated with …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

Background DNA methylation is strongly associated with smoking status at multiple sites
across the genome. Studies have largely been restricted to European origin individuals yet the …

Objective To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with
a functional role in cartilage homeostasis. Methods The expression of miRNAs was …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …

Epigenome-wide association studies (EWAS) seek to quantify associations between traits/exposures
and DNA methylation measured at thousands or millions of CpG sites across the …

Epigenetic mechanisms are believed to play an important role in disease, development and
ageing with early life representing a window of particular epigenomic plasticity. The …