'Eicosanoid'is a term coined to describe compounds derived from C 20 fatty acids [1]. The
term is now generally used to identify the paracrine hormones derived from free arachidonic …

… While the accumulation of the JE message continued for the four hours of these experiments,
the KC mRNA level peaked at one hour, then fell. Moreover cycloheximide inhibition did …

Noninvasive molecular-imaging technologies are providing researchers with exciting new
opportunities to study small-animal models of human disease. With continued improvements …

TISlO is a primary response gene whose cDNA was cloned as a result of its rapid,
superinducible expression in Swiss 3T3 cells in response to 12-0-tetradecanoylphorbol-13-acetate. …

Identifying the molecular targets for the beneficial or detrimental effects of small-molecule
drugs is an important and currently unmet challenge. We have developed a method, drug …

… Cells were pretreated with 0.3 mM MTA prior to incubation with IFNα for an additional 2 hr.
Total RNA was isolated and hybridized to riboprobes corresponding to the interferon-…

Type I protein arginine methyltransferases catalyze the formation of asymmetric ω-N G ,N G -dimethylarginine
residues by transferring methyl groups fromS-adenosyl-l-methionine to …

… Many immediate-early genes encode transcription factors (eg Fos, Jun, Egr-1) that
initiate transcriptional cascades required for proliferation or differentiation (Herschman, …

We are developing assays for noninvasive, quantitative imaging of reporter genes with
positron emission tomography (PET), for application both in animal models and in human gene …

We are developing quantitative assays to repeatedly and noninvasively image expression
of reporter genes in living animals, using positron emission tomography (PET). We …