… Ueda and colleagues took a system-level approach to identifying potent hydrophilic
tissue-clearing reagents by comprehensive chemical profiling. They discovered a series of amino …

Organism-level systems biology aims to identify, analyze, control and design cellular circuits
in organisms. Many experimental and computational approaches have been developed …

… Murakami & HR Ueda, unpublished results). This hypothesis of increased internal osmotic
pressure may also be supported by the empirical observation that tissues swollen due to …

This study describes comprehensive polling of transcription start and termination sites and
analysis of previously unidentified full-length complementary DNAs derived from the mouse …

Systems-level identification and analysis of cellular circuits in the brain will require the
development of whole-brain imaging with single-cell resolution. To this end, we performed …

Mammalian circadian clocks consist of complex integrated feedback loops 1 , 2 , 3 , 4 , 5 , 6 ,
7 , 8 , 9 , 10 that cannot be elucidated without comprehensive measurement of system …

Mammalian circadian clocks consist of complexly integrated regulatory loops 1 , 2 , 3 , 4 , 5 ,
making it difficult to elucidate them without both the accurate measurement of system …

DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation
in CpG dinucleotides in mammalian genomes, providing an epigenetic basis for gene …

Here we describe a protocol for advanced CUBIC (Clear, Unobstructed Brain/Body Imaging
Cocktails and Computational analysis). The CUBIC protocol enables simple and efficient …

Molecular mechanisms regulating animal seasonal breeding in response to changing
photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-…