Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone — the most common site of …

Patients with high-grade serous ovarian cancer (HGSC) have experienced little
improvement in overall survival, and standard treatment has not advanced beyond platinum-based …

Cardiac hypertrophy, induced by chronic pressure or volume overload, is associated with
abnormalities in energy metabolism as well as characteristic increases in muscle mass and …

Variations in sample quality are frequently encountered in small RNA-sequencing
experiments, and pose a major challenge in a differential expression analysis. Removal of high …

Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms
that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse …

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells.
Here, we show that oncogenic KRAS (KRAS G12D ) also regulates tumor cell signaling via …

B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity,
and Joining genes, and peripherally by somatic hypermutation and class-switching of the …

In most patients with small-cell lung cancer (SCLC)—a metastatic, aggressive disease—the
condition is initially chemosensitive but then relapses with acquired chemoresistance. In a …

Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs),
early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC …

We postulate that nanoparticles (NPs) for use in therapeutic applications have largely not
realized their clinical potential due to an overall inability to use in vitro results to predict NP …