[PDF][PDF] Determination and inference of eukaryotic transcription factor sequence specificity
Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only ∼1% of eukaryotic TFs. Broadly sampling DNA-binding domain (DBD…
currently known for only ∼1% of eukaryotic TFs. Broadly sampling DNA-binding domain (DBD…
A compendium of RNA-binding motifs for decoding gene regulation
RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …
been functionally characterized. Here we report a systematic analysis of the RNA motifs …
The human splicing code reveals new insights into the genetic determinants of disease
INTRODUCTION Advancing whole-genome precision medicine requires understanding
how gene expression is altered by genetic variants, especially those that are far outside of …
how gene expression is altered by genetic variants, especially those that are far outside of …
C2H2 zinc finger proteins greatly expand the human regulatory lexicon
HS Najafabadi, S Mnaimneh, FW Schmitges… - Nature …, 2015 - nature.com
Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative human
transcription factors. However, for most C2H2-ZF proteins it is unknown whether they even bind …
transcription factors. However, for most C2H2-ZF proteins it is unknown whether they even bind …
Spatially mapping the immune landscape of melanoma using imaging mass cytometry
Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …
Systematic discovery of structural elements governing stability of mammalian messenger RNAs
Decoding post-transcriptional regulatory programs in RNA is a critical step towards the
larger goal of developing predictive dynamical models of cellular behaviour. Despite recent …
larger goal of developing predictive dynamical models of cellular behaviour. Despite recent …
Multiparameter functional diversity of human C2H2 zinc finger proteins
FW Schmitges, E Radovani, HS Najafabadi… - Genome …, 2016 - genome.cshlp.org
C2H2 zinc finger proteins represent the largest and most enigmatic class of human transcription
factors. Their C2H2-ZF arrays are highly variable, indicating that most will have unique …
factors. Their C2H2-ZF arrays are highly variable, indicating that most will have unique …
Expression of DRD2 is increased in human pancreatic ductal adenocarcinoma and inhibitors slow tumor growth in mice
P Jandaghi, HS Najafabadi, AS Bauer, AI Papadakis… - Gastroenterology, 2016 - Elsevier
Background & Aims Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC),
the most common form of pancreatic cancer, are almost equivalent, so better treatments …
the most common form of pancreatic cancer, are almost equivalent, so better treatments …
[HTML][HTML] Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay.
Here, we present a method for unbiased estimation of differential mRNA decay rate from …
Here, we present a method for unbiased estimation of differential mRNA decay rate from …
A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements
INTRODUCTION Alternative splicing is a posttranscriptional regulatory mechanism critical
for transcriptome and proteome diversity. By increasing complexity at the protein level, …
for transcriptome and proteome diversity. By increasing complexity at the protein level, …