Proteasomes are large, multisubunit proteolytic complexes presenting multiple targets for
therapeutic intervention. The 26S proteasome consists of a 20S proteolytic core and one or two …

This tutorial review surveys the use of thioglycosides in the development of sequential
glycosylation methodologies, with a focus on chemoselective, orthogonal and iterative …

The discovery of the glycosphingolipids is generally attributed to Johan LWThudichum, who
in 1884 published on the chemical composition of the brain. In his studies he isolated …

AC‐terminally modified ubiquitin (Ub) derivative, ubiquitin vinyl sulfone (UbVS), was
synthesized as an active site‐directed probe that irreversibly modifies a subset of Ub C‐terminal …

A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in
the pathogenesis of insulin resistance. We have developed a highly specific small molecule …

A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to
the death of one volunteer and produced mild-to-severe neurological symptoms in four others…

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal
storage disorder. Carriership for Gaucher disease has recently been identified as major risk …

Diphenylsulfoxide in combination with triflic anhydride provides a very potent thiophilic
glycosylation promotor system, capable of activating disarmed thioglycosides. The usefulness of …

Here, we describe a new approach designed to monitor the proteolytic activity of maturing
phagosomes in live antigen-presenting cells. We find that an ingested particle sequentially …

The existence of a non-lysosomal glucosylceramidase in human cells has been documented
(van Weely, S., Brandsma, M., Strijland, A., Tager, JM, and Aerts, JMFG (1993) Biochim. …