Prostaglandin E 2 (PGE 2 ) is a crucial mediator of inflammatory pain sensitization. Here, we
demonstrate that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE 2 -…

Inflammatory diseases and neuropathic insults are frequently accompanied by severe and
debilitating pain, which can become chronic and often unresponsive to conventional …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in
different CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Despite the crucial role that prostaglandins (PGs) have in the sensitization of the central nervous
system to pain, their cellular and molecular targets leading to increased pain perception …

The gate control theory of pain proposes that inhibitory neurons of the spinal dorsal horn
exert critical control over the relay of nociceptive signals to higher brain areas. Here we …

Although glycine is a major inhibitory transmitter in the mammalian CNS, the role of glycinergic
neurons in defined neuronal circuits remains ill defined. This is due in part to difficulties in …

Alterations in synaptic transmission within the spinal cord dorsal horn play a key role in the
development of pathological pain. While N-methyl-D-aspartate (NMDA) receptors and activity-…

Blockade of prostaglandin (PG) production by COX inhibitors is the treatment of choice for
inflammatory pain but is also prone to severe side effects. Identification of signaling elements …

Postsynaptic scaffolding proteins ensure efficient neurotransmission by anchoring receptors
and signaling molecules in synapse-specific subcellular domains. In turn, posttranslational …

Ca 2+ -permeable AMPA receptors are densely expressed in the spinal dorsal horn, but
their functional significance in pain processing is not understood. By disrupting the genes …