Diverse inflammatory diseases, infections and malignancies are associated with wasting
syndromes. In many of these conditions, the standards for diagnosis and treatment are lacking …

Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial
role of intracellular metabolism in regulating immune cell function. Emerging insights into …

Targeted genomic regulation is a powerful approach to accelerate trait discovery and
development in agricultural biotechnology. Bacteria and archaea use clustered regularly …

Cachexia represents a leading cause of morbidity and mortality in various cancers, chronic
inflammation and infections. Understanding of the mechanisms that drive cachexia has …

Infections induce complex host responses linked to antiviral defense, inflammation, and
tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may …

Tissue damage caused by viral hepatitis is a major cause of morbidity and mortality worldwide.
Using a mouse model of viral hepatitis, we identified virus-induced early transcriptional …

The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible
devil facial tumor disease (DFTD). To unveil the molecular underpinnings of this transmissible …

… (C) Primary murine CD8 + T cells were activated for 36 h under indicated condition.
Numbers indicate frequencies of viable cells or lymphoblasts. Quantitative analysis is shown …

Developing targeted genome regulation approaches holds much promise for accelerating
trait discovery and development in agricultural biotechnology. Clustered Regularly …

… In mice, the α chain is encoded by the H-2D, H-2K and H-2L loci (5). Binding of the TCR to
the viral peptide-MHCI complex, together with sufficient costimulatory signals from receptor/…