Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment
options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was …

Ballistic movements like saccades require the brain to generate motor commands without
the benefit of sensory feedback. Despite this, saccades are remarkably accurate. Theory …

The cerebellum may monitor motor commands and through internal feedback correct for
anticipated errors. Saccades provide a test of this idea because these movements are …

Profound global loss of DNA methylation is a hallmark of many cancers. One potential
consequence of this is the reactivation of transposable elements (TEs) which could stimulate the …

Objectives Skin fibrosis mediated by activated dermal fibroblasts is a hallmark of systemic
sclerosis (SSc), especially in the subset of patients with diffuse disease. Transforming growth …

Cancer immunotherapy has emerged as an effective therapy in a variety of cancers. However,
a key challenge in the field is that only a subset of patients who receive immunotherapy …

Necroptosis is a form of programmed cell death that is defined by activation of the kinase
RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 activation …

Broadly neutralizing antibodies targeting the stalk region of influenza A virus (IAV)
hemagglutinin (HA) are effective in blocking virus infection both in vitro and in vivo. The highly …

PD-1 and PD-L1 act to restrict T cell responses in cancer and contribute to self-tolerance.
Consistent with this role, PD-1 checkpoint inhibitors have been associated with immune-…

MHAA4549A, a human monoclonal antibody targeting the hemagglutinin stalk region of
influenza A virus (IAV), is being developed as a therapeutic for patients hospitalized with severe …