Comparative gene identification-58 (CGI-58), also designated as α/β-hydrolase domain
containing-5 (ABHD-5), is a lipid droplet-associated protein that activates adipose triglyceride …

10.7554/eLife.25125.001 To determine the dynamics of allelic-specific expression during
mouse development, we analyzed RNA-seq data from 23 F1 tissues from different …

Proteolytic activity of separase is required for chiasma resolution during meiosis I in mouse
oocytes. Rec8, the meiosis-specific α-kleisin subunit of cohesin, is a key target of separase in …

Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways
in heart. Here we show that mice lacking junD develop less adaptive hypertrophy in heart …

Fertilization is the fundamental process that initiates the development of a new individual in
all sexually reproducing species. Despite its importance, our understanding of the molecular …

The activator protein 1 (AP-1) member JunB has recently been implicated in leukemogenesis.
Here we surveyed human lymphoma samples for expression of JunB and other AP-1 …

Degradation of nuclear DNA is a hallmark of programmed cell death. Epidermal keratinocytes
die in the course of cornification to function as the dead building blocks of the cornified …

Stem cell-specific transcriptional networks are well known to control pluripotency, but
constitutive cellular processes such as mRNA splicing and protein synthesis can add complex …

Long non-coding (lnc) RNAs are numerous and found throughout the mammalian genome,
and many are thought to be involved in the regulation of gene expression. However, the …

Genomic imprinting is widely conserved amongst placental mammals. Imprinted expression
of IGF2R, however, differs between mice and humans. In mice, Igf2r imprinted expression is …