Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

The accumulation of epigenetic changes was proposed to contribute to the age‐related
increase in the risk of most common diseases. In this study on 230 monozygotic twin pairs (MZ …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

Background DNA methylation has been recognized as a key mechanism in cell differentiation.
Various studies have compared tissues to characterize epigenetically regulated genomic …

Over the past 25 years, the Adult Netherlands Twin Register (ANTR) has collected a wealth
of information on physical and mental health, lifestyle, and personality in adolescents and …

Animal lifespan is regulated by conserved metabolic signalling pathways and specific
transcription factors, but whether these pathways affect common downstream mechanisms …

In 2004 the Netherlands Twin Register (NTR) started a large scale biological sample collection
in twin families to create a resource for genetic studies on health, lifestyle and personality…

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

Background: The manipulation of pregnancy diets in animals can lead to changes in DNA
methylation with phenotypic consequences in the offspring. Human studies have concentrated …