Background and purpose The Japanese Clinical Practice Guidelines for Management of
Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice …

Octacalcium phosphate (Ca8H2(PO4)6.5H2O; OCP) has been advocated to be a precursor
of biological apatite crystals in bone and tooth. Recent studies, using physical techniques, …

Background Faricimab is a bispecific antibody that acts through dual inhibition of both
angiopoietin-2 and vascular endothelial growth factor A. We report primary results of two phase 3 …

Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered
anatomy must be performed by a highly experienced endoscopist. The challenges are …

… Forty-eight hours after transfection, the cells were stimulated with the indicated concentrations
of zymosan for 18 h, and luciferase activity was measured by the Dual Luciferase reporter …

… h (runs 1−5, 7, and 8) or in THF/acetone (1/1, v/v) for 5 h (run 6). Concentrations of the
assembled precursors: 0.06 g/L (run 8), 0.1 g/L (run 2), 0.2 g/L (runs 1, 3, 5, and 6), 5.0 g/L (run 7), …

Objective— High mobility group box 1 protein (HMGB1) was identified as a mediator of
endotoxin lethality. We previously reported that thrombomodulin (TM), an endothelial thrombin-…

Octacalcium phosphate (OCP) is thought to be a precursor of the mineral crystals in biological
apatite. Synthetic OCP has been shown to be converted into an apatite structure when …

Methods: Hypotensive sepsis was studied in male Sprague-Dawley rats using cecal ligation
and perforation, with a 6-hour end point. Rat hindlimb skeletal muscle microcirculation was …

Results: The carcinoid tumors measured 10 mm or less in four of the five patients. Two patients
had type A gastritis, and all had hypergastrinemia. There was no evidence of recurrence …