User profiles for H. J. Cools

Hans Cools

Syngenta
Verified email at syngenta.com
Cited by 3880

Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future control

HJ Cools, BA Fraaije - Pest management science, 2013 - Wiley Online Library
This review summarises recent investigations into the molecular mechanisms responsible
for the decline in sensitivity to azole (imidazole and triazole) fungicides in European …

Constraints on the evolution of azole resistance in plant pathogenic fungi

HJ Cools, NJ Hawkins, BA Fraaije - Plant Pathology, 2013 - Wiley Online Library
The durability of azole fungicides in controlling agriculturally important pathogenic fungi is
unique amongst modern single site fungicides. Today, azoles are still relied on to control …

[HTML][HTML] Finished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth …

…, ACL Churchill, L Conde-Ferràez, HJ Cools… - PLoS …, 2011 - journals.plos.org
The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici)
causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat. This …

Exploitation of genomics in fungicide research: current status and future perspectives

HJ Cools, KE Hammond‐Kosack - Molecular plant pathology, 2013 - Wiley Online Library
Every year, fungicide use to control plant disease caused by pathogenic fungi increases. The
global fungicide market is now worth more than £5.3 billion, second only to the herbicide …

Role of Ascospores in Further Spread of QoI-Resistant Cytochrome b Alleles (G143A) in Field Populations of Mycosphaerella graminicola

BA Fraaije, HJ Cools, J Fountaine, DJ Lovell… - …, 2005 - Am Phytopath Society
Strobilurin fungicides or quinone outside inhibitors (QoIs) have been used successfully to
control Septoria leaf blotch in the United Kingdom since 1997. However, QoI-resistant isolates …

Risk assessment studies on succinate dehydrogenase inhibitors, the new weapons in the battle to control Septoria leaf blotch in wheat

BA Fraaije, C Bayon, S Atkins, HJ Cools… - Molecular Plant …, 2012 - Wiley Online Library
Chemical control of Septoria leaf blotch, caused by Mycosphaerella graminicola, is essential
to ensure wheat yield and food security in most European countries. Mycosphaerella …

Overexpression of the sterol 14α‐demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotype

HJ Cools, C Bayon, S Atkins, JA Lucas… - Pest management …, 2012 - Wiley Online Library
BACKGROUND: The recent evolution towards resistance to azole fungicides in European
populations of the wheat pathogen Mycosphaerella graminicola has been caused by the …

A novel substitution I381V in the sterol 14α‐demethylase (CYP51) of Mycosphaerella graminicola is differentially selected by azole fungicides

BA Fraaije, HJ Cools, SH Kim… - Molecular Plant …, 2007 - Wiley Online Library
The recent reduction in the efficacy of azole fungicides in controlling Septoria leaf blotch of
wheat, caused by Mycosphaerella graminicola, has prompted concerns over possible …

Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicola

HJ Cools, BA Fraaije - Pest Management Science: Formerly …, 2008 - Wiley Online Library
… Hans J CoolsCools and Bart A. Fraaije ask the question: can widespread resistance
to all azoles develop in this pathogen? Copyright © 2008 Society of Chemical Industry …

Characterization of the sterol 14α‐demethylases of Fusarium graminearum identifies a novel genus‐specific CYP51 function

…, BA Fraaije, X Liu, HJ Cools - New …, 2013 - Wiley Online Library
… cerevisiae YUG37::erg11 followed the method described by Cools et al. (2010). FgCYP51
… Mycosphaerella graminicola azole sensitivity and enzyme function (Cools et al., 2010, 2011) …