Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …

The colonic epithelium facilitates host–microorganism interactions to control mucosal
immunity, coordinate nutrient recycling and form a mucus barrier. Breakdown of the epithelial …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through time. …

… h, Upset plot showing TCR clones shared between different clusters, each shared clone
visualized as an ‘interaction’ and indicated by a black circle joined by black lines. Each unique …

A left R-module M is called weakly prime module if the annihilator of any nonzero submodule
of M is a prime ideal and a proper submodule P of M is called weakly prime submodule if …

Background: The newly identified coronavirus known as 2019-nCoV has posed a serious
global health threat. According to the latest report (18-February-2020), it has infected more …

While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad
range in susceptibility and severity to the disease, the pre-existing immune memory to related …

Genome-wide profiling of open chromatin regions using DNase I and high-throughput
sequencing (DNase-seq) is an increasingly popular approach for finding and studying regulatory …