Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies
to humans. Recent research has revealed that the planar organization of cells requires a …

Signal transduction pathways interact at various levels to define tissue morphology, size
and differentiation during development. Understanding the mechanisms by which these …

Control of cell number requires the coordinate regulation of cell proliferation and cell death.
Studies in both the fly and mouse have identified the Hippo kinase pathway as a key …

Several developmental pathways contribute to processes that regulate tissue growth and
organ size. The Hippo pathway has emerged as one such critical regulator. However, how …

… We dissected the inner ears from newborn wild-type and Fat4 −/− mutants in cold PBS and
fixed them at room temperature for 2 h in 2.5% glutaraldehyde in 0.1M sodium cacodylate …

… d, ft G-rv mutant clone in a 30-h pupal wing showing GFP clone marker and Dsh::GFP. Dsh::…
e, f, Anti-βGal staining of fj-lacZ in a 24-h pupal wing (e), and Ds antibody staining in a 24-h …

Na+, K+-ATPase has distinctly different distributions in mesenchymal cells, where it has an
unrestricted distribution over the entire cell surface, compared with polarized epithelial cells, …

… We find that loss of ft leads to increases in Cyclin E expression throughout the eye disc, most
strikingly, in cells posterior to the MF (Figure 1H). Overexpression of Cyclin E is common in …

Yap is a transcriptional co-activator that regulates cell proliferation and apoptosis
downstream of the Hippo kinase pathway. We investigated Yap function during mouse kidney …

The t (8; 21) translocation fuses the DNA-binding domain of the hematopoietic master
regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-…