[HTML][HTML] Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy
HM Moulton, JD Moulton - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Exon-skipping efficacies of phosphodiamidate morpholino oligomers (PMOs) or the conjugates
of PMOs with cell-penetrating peptides (PPMOs) have been tested in various animal …
of PMOs with cell-penetrating peptides (PPMOs) have been tested in various animal …
Cell penetrating peptide conjugates of steric block oligonucleotides
B Lebleu, HM Moulton, R Abes, GD Ivanova… - Advanced drug delivery …, 2008 - Elsevier
… by the cellular enzyme RNase H results in subsequent RNA … are not substrates for RNase
H when duplexed to RNA have … molecular recognition by cellular RNase H. Instead, the only …
H when duplexed to RNA have … molecular recognition by cellular RNase H. Instead, the only …
TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
…, H Limburg, O Pilgram, H Moulton… - Life science …, 2020 - life-science-alliance.org
… , Calu-3 cells were treated with PPMO for 24 h before infection, then inoculated with virus
at an MOI of 0.001 for 1 h 30 min, and incubated for 72 h in the absence of further PPMO, as …
at an MOI of 0.001 for 1 h 30 min, and incubated for 72 h in the absence of further PPMO, as …
Cell-penetrating-peptide-based delivery of oligonucleotides: an overview
R Abes, AA Arzumanov, HM Moulton… - Biochemical Society …, 2007 - portlandpress.com
… Co-administration of chloroquine, an endosomolytic agent, enabled inhibition to be
observed only 6 h after delivery and, in some cases, caused inactive CPP–PNA conjugates to …
observed only 6 h after delivery and, in some cases, caused inactive CPP–PNA conjugates to …
[PDF][PDF] Meta-and orthogonal integration of influenza “OMICs” data defines a role for UBR4 in virus budding
Several systems-level datasets designed to dissect host-pathogen interactions during influenza
A infection have been reported. However, apparent discordance among these data has …
A infection have been reported. However, apparent discordance among these data has …
Active specific immunotherapy with a β-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated …
HM Moulton, PH Yoshihara, DH Mason, PL Iversen… - Clinical Cancer …, 2002 - AACR
Purpose: Human chorionic gonadotropin (hCG) is produced by colorectalcancers and may
play a role in its progression. The clinical and immunological effects of a synthetic vaccine …
play a role in its progression. The clinical and immunological effects of a synthetic vaccine …
[BOOK][B] A concordance to the Greek Testament, according to the texts of Westcott and Hort, Tischendorf, and the English revisers
WF Moulton, AS Geden, HK Moulton - 1978 - books.google.com
… JH Moulton, MA, who has rendered most generous assistance by reading through with me
all the proof-sheets, and whose scholarly care has borne fruit on every page of the work. And if …
all the proof-sheets, and whose scholarly care has borne fruit on every page of the work. And if …
[HTML][HTML] Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice
N Jearawiriyapaisarn, HM Moulton, B Buckley… - Molecular Therapy, 2008 - cell.com
Cell-penetrating peptides (CPPs), containing arginine (R), 6-aminohexanoic acid (X), and/or
β-alanine (B) conjugated to phosphorodiamidate morpholino oligomers (PMOs), enhance …
β-alanine (B) conjugated to phosphorodiamidate morpholino oligomers (PMOs), enhance …
Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer
B Wu, HM Moulton, PL Iversen… - Proceedings of the …, 2008 - National Acad Sciences
… Sequencing of the 880-bp RT-PCR product confirmed the skipping of the exon 23 (H). … 1H).
Restoration of dystrophin expression also restored the α dystroglycan, α sarcoglycan, and β …
Restoration of dystrophin expression also restored the α dystroglycan, α sarcoglycan, and β …
Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD
G McClorey, HM Moulton, PL Iversen, S Fletcher… - Gene therapy, 2006 - nature.com
Manipulation of pre-mRNA splicing by antisense oligonucleotides (AOs) offers considerable
potential for a number of genetic disorders. One of these is Duchenne muscular dystrophy (…
potential for a number of genetic disorders. One of these is Duchenne muscular dystrophy (…