… We have also positioned the H/ACA snoRNP component Cbf5 such that it can access a
hypothetical intron-encoded small nucleolar RNA (snoRNA) (red recognition sequence indicated …

Astrocytes contribute to the maintenance of the health and function of the central nervous
system (CNS). Thus, it is not surprising that these multifunctional cells have been implicated in …

Cellular senescence is a well-established driver of aging and age-related diseases. There
are many challenges to mapping senescent cells in tissues such as the absence of specific …

… dish was then washed three times with 10–20 ml of DPBS and incubated with the corresponding
primary antibodies diluted in 12 ml of DPBS/0.2% BSA solution per dish for at least 2 h …

To better understand host-virus genetic dependencies and find potential therapeutic targets
for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify …

Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic
lateral sclerosis and frontotemporal dementia 1 , 2 – 3 , two related neurodegenerative …

… of Siglec-H and Olfml3 by flow cytometry and immunostaining (Figures 2E, 3C, and S2). As
indicated by FACS, the spleen, liver, and lymph node macrophages did not express Siglec-H, …

… 3B shows a 3.5-h exposure, it is noteworthy that a 90-h exposure revealed a potential weak
interaction of Set2 (1-618) to phosphorylated CTD (data not shown); however, it is unclear …

Drosophila contains one (dCDK12) and humans contain two (hCDK12 and hCDK13) proteins
that are the closest evolutionary relatives of yeast Ctk1, the catalytic subunit of the major …

Transactive response DNA-binding (TDP-43) protein is the dominant disease protein in
amyotrophic lateral sclerosis (ALS) and a subgroup of frontotemporal lobar degeneration (FTLD-…