[HTML][HTML] Development of therapeutic antibodies for the treatment of diseases
… C H : domains of the constant region of the heavy chain; C L : constant domain of the light
chain; Fab and Fc: fragments resulting from proteolysis; V H : variable domain of the heavy …
chain; Fab and Fc: fragments resulting from proteolysis; V H : variable domain of the heavy …
[HTML][HTML] Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance
H Easwaran, HC Tsai, SB Baylin - Molecular cell, 2014 - cell.com
The existence of subpopulations of cells in cancers with increased tumor-initiating capacities
and self-renewal potential, often termed "cancer stem cells," is a much discussed and key …
and self-renewal potential, often termed "cancer stem cells," is a much discussed and key …
Astrocytes and disease: a neurodevelopmental perspective
AV Molofsky, R Krenick, E Ullian, H Tsai… - Genes & …, 2012 - genesdev.cshlp.org
Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …
High-efficiency solution-processed perovskite solar cells with millimeter-scale grains
State-of-the-art photovoltaics use high-purity, large-area, wafer-scale single-crystalline
semiconductors grown by sophisticated, high-temperature crystal growth processes. We …
semiconductors grown by sophisticated, high-temperature crystal growth processes. We …
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
…, EE Bouhassira, JD Upshaw Jr, D Ginsburg, HM Tsai - Nature, 2001 - nature.com
Thrombotic thrombocytopenic purpura (TTP) is a life-threatening systemic illness of abrupt
onset and unknown cause. Proteolysis of the blood-clotting protein von Willebrand factor (VWF…
onset and unknown cause. Proteolysis of the blood-clotting protein von Willebrand factor (VWF…
High-efficiency two-dimensional Ruddlesden–Popper perovskite solar cells
… From the light stress tests for the 3D perovskites, we conclude that the observed degradation
in the first 10 h in the encapsulated and unencapsulated devices is similar, and so is …
in the first 10 h in the encapsulated and unencapsulated devices is similar, and so is …
High-spin molecules:[Mn12O12 (O2CR) 16 (H2O) 4]
… The mixture was stirred for 4 h and filtered to remove a small amount of undissolved solid.
Hexanes (100 mL) were added to the filtrate, and the solution was stored overnight at room …
Hexanes (100 mL) were added to the filtrate, and the solution was stored overnight at room …
[HTML][HTML] Antibodies to von Willebrand factor–cleaving protease in acute thrombotic thrombocytopenic purpura
HM Tsai, ECY Lian - New England Journal of Medicine, 1998 - Mass Medical Soc
Background Thrombotic thrombocytopenic purpura is a potentially fatal disease characterized
by widespread platelet thrombi in the microcirculation. In the normal circulation, von …
by widespread platelet thrombi in the microcirculation. In the normal circulation, von …
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning
Natural rewards and drugs of abuse can alter dopamine signaling, and ventral tegmental
area (VTA) dopaminergic neurons are known to fire action potentials tonically or phasically …
area (VTA) dopaminergic neurons are known to fire action potentials tonically or phasically …
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
… Given the striking impairment in sucrose preference approximately 12 h after the optogenetic
activation of VTA neurons, we proposed that such stimulation might induce lasting changes …
activation of VTA neurons, we proposed that such stimulation might induce lasting changes …