Background and hypothesis Based on neurochemical and genetic evidence, we suggest
that both prevention and treatment of multiple addictions, such as dependence to alcohol, …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

… Watching tele- vision and using the Internet Daily television time (<2 h; 2 to <4 h; 4 to <6 h;
≥6 h/d) 3 different types of PA: >1/wk; once a wk; 1–3 times/mo Follow up 1 year Muscle …

The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles
in perception, cognition, emotion, and learning. We profiled ∼1.3 million cells covering the …

… Phospho-DARPP-32 and phospho-inhibitor-1, each at 10 " M and each containing 1 mol
phosphate per mol protein, were preincubated at 30 C for 2 h in the absence or presence of 50 …

Objectives Poor sleep quality is a common issue among older adults; it can lead to a poor
quality of life and impairments in cognitive function and physical health. This study aimed to …

… Error bars show sd h, Average number of differentially expressed genes between indicated
cluster and other homologous t-types. i, Comparison of calculated electrophysiological …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Changing collective behaviour and supporting non-pharmaceutical interventions is an
important component in mitigating virus transmission during a pandemic. In a large international …

10.7554/eLife.16351.001 The FDA approved drug rapamycin increases lifespan in rodents
and delays age-related dysfunction in rodents and humans. Nevertheless, important …