Quorum sensing as an integral component of gene regulatory networks in Gram-negative bacteria

H Withers, S Swift, P Williams - Current opinion in microbiology, 2001 - Elsevier
Bacterial cell-to-cell communication (quorum sensing) relies upon the interaction of a small
diffusible signal molecule with a sensor or transcriptional activator to couple gene expression …

Evidence-based management of groin hernia in primary care—a systematic review

…, A Hutchinson, A Roberts, H Withers - Family Practice, 2000 - academic.oup.com
Background. National clinical guidelines on the surgical management of groin hernia have
been published by the Royal College of Surgeons of England. There is also a need for …

The hazard of accelerated tumor clonogen repopulation during radiotherapy

HR Withers, JMG Taylor, B Maciejewski - Acta oncologica, 1988 - Taylor & Francis
When analysis of results of radiotherapy for nearly 500 patients with oropharyngeal cancer
showed evidence for rapid tumor regrowth during extensions of treatment from about 5 weeks …

Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships

HD Thames Jr, HR Withers, LJ Peters… - International Journal of …, 1982 - Elsevier
Clinical and experimental evidence for divergent changes in early and late radiation responses
in normal tissues after changes in dose fractionation indicate a greater sensitivity of late …

Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation

HR Withers, MM Elkind - … Journal of Radiation Biology and Related …, 1970 - Taylor & Francis
A microcolony technique for assaying the survival of small proportions of the clonogenic cells
of the mucosa of the small intestine of mice is described. The radiosensitivity of intestinal …

Applying radiobiological principles to combined modality treatment of head and neck cancer--the time factor.

LJ Peters, HR Withers - International journal of radiation oncology …, 1997 - europepmc.org
Purpose Combined modality treatment is indicated for most advanced stage head and neck
cancers. It is postulated that the efficacy of combined modality regimens could be enhanced …

Treatment volume and tissue tolerance

HR Withers, JMG Taylor, B Maciejewski - International Journal of Radiation …, 1988 - Elsevier
Hypotheses regarding tissue organization and radiation response were described and, on
the basis of simple modeling, tentative conclusions were drawn regarding the influence on “…

The four R's of radiotherapy

HR Withers - Advances in radiation biology, 1975 - Elsevier
Publisher Summary Radiotherapy given as multiple doses are effective in sterilizing cancers,
but the processes whereby the neoplasm is eradicated and the normal tissues are …

Induction of acute phase gene expression by brain irradiation

…, CS Chiang, IL Campbell, JR Sun, HR Withers… - International Journal of …, 1995 - Elsevier
Purpose : To investigate the in vivo acute phase molecular response of the brain to ionizing
radiation. Methods and Materials : C3Hf/Sed/Kam mice were given midrain or whole-body …

Biologic basis for altered fractionation schemes

HR Withers - Cancer, 1985 - Wiley Online Library
Conventional is commonly not universally correct, and so with dose fractionation in radiotherapy.
Fractionation spares slowly responding tissues more than tissues and tumors that show …