… Golden JA, Nadel JA, Boushey HA. Bronchial hyperirritability in healthy subjects after
exposure to ozone. Am Rev Respir Dis 1978; 118:287-94. … Holtzman MJ, Cunningham JH …

The application of recently developed sensitive, specific, culture-independent tools for
identification of microbes is transforming concepts of microbial ecology, including concepts of the …

BACKGROUND: The goals of asthma treatment include preventing recurrent exacerbations.
Yet there is no consensus about the terminology for describing or defining “exacerbation” or …

For most patients, asthma is not controlled as defined by guidelines; whether this is achievable
has not been prospectively studied. A 1-year, randomized, stratified, double-blind, parallel…

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

Gut microbiota bacterial depletions and altered metabolic activity at 3 months are implicated
in childhood atopy and asthma 1 . We hypothesized that compositionally distinct human …

The detection of viral pathogens is of critical importance in biology, medicine, and agriculture.
Unfortunately, existing techniques to screen for a broad spectrum of viruses suffer from …

Airway inflammation and epithelial remodeling are two key features of asthma. IL-13 and
other cytokines produced during T helper type 2 cell-driven allergic inflammation contribute to …

A humanized murine monoclonal antibody directed to the Fc epsilonR1-binding domain of
human IgE (rhuMAb-E25) has been shown to inhibit the binding of IgE to mast cells without …

Concepts of asthma severity and control are important in the evaluation of patients and their
response to treatment but the terminology is not standardised and the terms are often used …