Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows

L Excoffier, HEL Lischer - Molecular ecology resources, 2010 - Wiley Online Library
We present here a new version of the Arlequin program available under three different forms:
a Windows graphical version (Winarl35), a console version of Arlequin (arlecore), and a …

PGDSpider: an automated data conversion tool for connecting population genetics and genomics programs

HEL Lischer, L Excoffier - Bioinformatics, 2012 - academic.oup.com
The analysis of genetic data often requires a combination of several approaches using
different and sometimes incompatible programs. In order to facilitate data exchange and file …

[HTML][HTML] Reference-guided de novo assembly approach improves genome reconstruction for related species

HEL Lischer, KK Shimizu - BMC bioinformatics, 2017 - Springer
Background The development of next-generation sequencing has made it possible to sequence
whole genomes at a relatively low cost. However, de novo genome assemblies remain …

[HTML][HTML] Avoiding the pitfalls of gene set enrichment analysis with SetRank

C Simillion, R Liechti, HEL Lischer, V Ioannidis… - BMC …, 2017 - Springer
Background The purpose of gene set enrichment analysis (GSEA) is to find general trends in
the huge lists of genes or proteins generated by many functional genomics techniques and …

Ignoring Heterozygous Sites Biases Phylogenomic Estimates of Divergence Times: Implications for the Evolutionary History of Microtus Voles

HEL Lischer, L Excoffier, G Heckel - Molecular Biology and …, 2014 - academic.oup.com
Phylogenetic reconstruction of the evolutionary history of closely related organisms may be
difficult because of the presence of unsorted lineages and of a relatively high proportion of …

[HTML][HTML] Monocyte biology conserved across species: Functional insights from cattle

SC Talker, GT Barut, HEL Lischer, R Rufener… - Frontiers in …, 2022 - frontiersin.org
Similar to human monocytes, bovine monocytes can be split into CD14 high CD16 - classical,
CD14 high CD16 high intermediate and CD14 -/dim CD16 high nonclassical monocytes (…

Molecular characterization of cell types in the squid Loligo vulgaris

…, M Sprecher, JC Kaldun, AS Al-Soudy, HEL Lischer… - Elife, 2023 - elifesciences.org
Cephalopods are set apart from other mollusks by their advanced behavioral abilities and
the complexity of their nervous systems. Because of the great evolutionary distance that …

[HTML][HTML] Patterns of polymorphism and selection in the subgenomes of the allopolyploid Arabidopsis kamchatica

…, G Halstead-Nussloch, HEL Lischer… - Nature …, 2018 - nature.com
Genome duplication is widespread in wild and crop plants. However, little is known about
genome-wide selection in polyploids due to the complexity of duplicated genomes. In …

Batch effects in a multiyear sequencing study: False biological trends due to changes in read lengths

DM Leigh, HEL Lischer, C Grossen… - Molecular Ecology …, 2018 - Wiley Online Library
High‐throughput sequencing is a powerful tool, but suffers biases and errors that must be
accounted for to prevent false biological conclusions. Such errors include batch effects; …

[HTML][HTML] Dual targeting of JAK2 and ERK interferes with the myeloproliferative neoplasm clone and enhances therapeutic efficacy

…, S Dirnhofer, G Hutter, K Leonards, HEL Lischer… - Leukemia, 2021 - nature.com
Myeloproliferative neoplasms (MPN) show dysregulated JAK2 signaling. JAK2 inhibitors
provide clinical benefits, but compensatory activation of MAPK pathway signaling impedes …