Although prime editors are a powerful tool for genome editing, which can generate various
types of mutations such as nucleotide substitutions, insertions, and deletions in the genome …

Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance
of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers…

CRISPR-based base editors (BEs) are widely used to induce nucleotide substitutions in living
cells and organisms without causing the damaging DNA double-strand breaks and DNA …

The bacteria-derived clustered regularly interspaced short palindromic repeat (CRISPR)–Cas
systems are powerful tools for genome engineering. Recently, in addition to Cas protein …

Lesch-Nyhan syndrome (LNS) is inherited as an X-linked recessive genetic disorder caused
by mutations in hypoxanthine-guanine phosphoribosyl transferase 1 (HPRT1). Patients with …

Various CRISPR‒Cas9 orthologs are used in genome engineering. One of the smallest Cas9
orthologs is cjCas9 derived from Campylobacter jejuni, which is a highly specific genome …

The CRISPR-Cas9 system has significantly advanced regenerative medicine research by
enabling genome editing in stem cells. Due to their desirable properties, mesenchymal stem …

TNF-α plays a crucial role in cancer initiation and progression by enhancing cancer cell
proliferation, survival, and migration. Even though the known functional role of AWP1 (zinc finger …

This study is to analyze the spatio-temporal trend of snowfall using 30 years (1980-2010)
data for 5 selected heavy snowfall areas (Ulleungdo (a), Northeastern Region (b), Western …

Patent foramen ovale (PFO) is being increasingly recognized as a mediator of paradoxical
embolism. 1–3 Transthoracic echocardiography (TTE) with contrast injection has been used …