[PDF][PDF] Principles of long noncoding RNA evolution derived from direct comparison of transcriptomes in 17 species
H Hezroni, D Koppstein, MG Schwartz, A Avrutin… - Cell reports, 2015 - cell.com
The inability to predict long noncoding RNAs from genomic sequence has impeded the use
of comparative genomics for studying their biology. Here, we develop methods that use RNA …
of comparative genomics for studying their biology. Here, we develop methods that use RNA …
[PDF][PDF] Tumor-reactive antibodies evolve from non-binding and autoreactive precursors
…, A Hanuna, Y Divinsky, MD Shmueli, H Hezroni… - Cell, 2022 - cell.com
The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a
favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and …
favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic and …
[HTML][HTML] Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation
S Melcer, H Hezroni, E Rand, M Nissim-Rafinia… - Nature …, 2012 - nature.com
Embryonic stem cells are characterized by unique epigenetic features including decondensed
chromatin and hyperdynamic association of chromatin proteins with chromatin. Here we …
chromatin and hyperdynamic association of chromatin proteins with chromatin. Here we …
H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells
The pluripotent genome is characterized by unique epigenetic features and a decondensed
chromatin conformation. However, the relationship between epigenetic regulation and …
chromatin conformation. However, the relationship between epigenetic regulation and …
[HTML][HTML] A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes
H Hezroni, R Ben-Tov Perry, Z Meir, G Housman… - Genome biology, 2017 - Springer
Background Only a small portion of human long non-coding RNAs (lncRNAs) appear to be
conserved outside of mammals, but the events underlying the birth of new lncRNAs in …
conserved outside of mammals, but the events underlying the birth of new lncRNAs in …
[PDF][PDF] Regulation of neuroregeneration by long noncoding RNAs
RBT Perry, H Hezroni, MJ Goldrich, I Ulitsky - Molecular cell, 2018 - cell.com
In mammals, neurons in the peripheral nervous system (PNS) have regenerative capacity
following injury, but it is generally absent in the CNS. This difference is attributed, at least in …
following injury, but it is generally absent in the CNS. This difference is attributed, at least in …
[HTML][HTML] Pluripotency-related, valproic acid (VPA)-induced genome-wide histone H3 lysine 9 (H3K9) acetylation patterns in embryonic stem cells
H Hezroni, BS Sailaja, E Meshorer - Journal of Biological Chemistry, 2011 - ASBMB
Embryonic stem cell (ESC) chromatin is characterized by a unique set of histone modifications,
including enrichment for H3 lysine 9 acetylation (H3K9ac). Recent studies suggest that …
including enrichment for H3 lysine 9 acetylation (H3K9ac). Recent studies suggest that …
[PDF][PDF] Deterministic somatic cell reprogramming involves continuous transcriptional changes governed by Myc and epigenetic-driven modules
…, YS Manor, V Krupalnik, M Zerbib, H Hezroni… - Cell Stem Cell, 2019 - cell.com
The epigenetic dynamics of induced pluripotent stem cell (iPSC) reprogramming in correctly
reprogrammed cells at high resolution and throughout the entire process remain largely …
reprogrammed cells at high resolution and throughout the entire process remain largely …
[HTML][HTML] Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells
…, A Gianotti-Sommer, SS Shen, BS Sailaja, H Hezroni… - PLoS …, 2012 - journals.plos.org
Delivery of the transcription factors Oct4, Klf4, Sox2 and c-Myc via integrating viral vectors
has been widely employed to generate induced pluripotent stem cell (iPSC) lines from both …
has been widely employed to generate induced pluripotent stem cell (iPSC) lines from both …
[PDF][PDF] YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation
Antibody-mediated immunity is initiated by B cell differentiation into multiple cell subsets,
including plasmablast, memory, and germinal center (GC) cells. B cell differentiation …
including plasmablast, memory, and germinal center (GC) cells. B cell differentiation …