Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …

Phosphorylation offers a dynamic way to regulate protein activity and subcellular localization,
which is achieved through its reversibility and fast kinetics. Adding or removing a dianionic …

Many soluble and membrane proteins form homooligomeric complexes in a cell which are
responsible for the diversity and specificity of many pathways, may mediate and regulate …

Posttranslational modifications offer a dynamic way to regulate protein activity, subcellular
localization, and stability. Here we estimate the effect of phosphorylation on protein binding …

Many studies have shown that missense mutations might play an important role in carcinogenesis.
However, the extent to which cancer mutations might affect biomolecular interactions …

The Protein Data Bank Japan (PDBj), a member of the worldwide Protein Data Bank (wwPDB),
accepts and processes the deposited data of experimentally determined biological …

Phosphorylation offers a dynamic way to regulate protein activity, subcellular localization,
and stability. The majority of signaling pathways involve an extensive set of protein–protein …

Cellular fate depends on the spatiotemporal separation and integration of signaling processes
that can be provided by phosphorylation events. In this study, we identify the crucial …

Protein homooligomers afford several important benefits for the cell; they mediate and
regulate gene expression, activity of many enzymes, ion channels, receptors, and cell–cell …

Despite the advances in surface-display systems for directed evolution, variants with high
affinity are not always enriched due to undesirable biases that increase target-unrelated …