Specialized somatosensory neurons detect temperatures ranging from pleasantly cool or
warm to burning hot and painful (nociceptive). The precise temperature ranges sensed by …

Voltage-gated Na + (Na V ) channels initiate neuronal action potentials. Na V channels are
composed of a transmembrane domain responsible for voltage-dependent Na + conduction …

Disruptions in the ubiquitin protein ligase E3A (UBE3A) gene cause Angelman syndrome (AS).
Whereas AS model mice have associated synaptic dysfunction and altered plasticity with …

Ca 2+ regulates voltage-gated Na + (Na V ) channels, and perturbed Ca 2+ regulation of Na
V function is associated with epilepsy syndromes, autism and cardiac arrhythmias. …

We previously reported a new line of Shank3 mutant mice which led to a complete loss of
Shank3 by deleting exons 4−22 (Δe4−22) globally. Δe4−22 mice display robust ASD-like …

Fibroblast growth factor homologous factors (FHFs) are not growth factors, but instead bind
to voltage-gated Na + channels (Na V ) and regulate their function. Mutations in FGF14, an …

10.7554/eLife.04193.001 Rapid firing of cerebellar Purkinje neurons is facilitated in part by
a voltage-gated Na + (Na V ) ‘resurgent’ current, which allows renewed Na + influx during …

Background Autism spectrum disorder involves neurodevelopmental dysregulations that
lead to visible symptoms at early stages of life. Many autism spectrum disorder–related …

Na v channels are essential for metazoan membrane depolarization, and Na v channel
dysfunction is directly linked with epilepsy, ataxia, pain, arrhythmia, myotonia, and irritable bowel …

Increased “persistent” current, caused by delayed inactivation, through voltage-gated Na + (Na
V ) channels leads to cardiac arrhythmias or epilepsy. The underlying molecular …