G-protein-coupled receptors (GPCRs) signal primarily through G proteins or arrestins. Arrestin
binding to GPCRs blocks G protein interaction and redirects signalling to numerous G-…

Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure
determination of challenging membrane proteins. Here we present a technique for extruding …

The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to more than 270 million
infections and 5.3 million of deaths worldwide. Several major variants of SARS-CoV-2 have …

Within a short period of time, COVID-19 grew into a world-wide pandemic. Transmission by
pre-symptomatic and asymptomatic viral carriers rendered intervention and containment of …

Photosynthesis, a process catalysed by plants, algae and cyanobacteria converts sunlight
to energy thus sustaining all higher life on Earth. Two large membrane protein complexes, …

The cannabinoid receptor 1 (CB 1 ) is the principal target of the psychoactive constituent of
marijuana, the partial agonist Δ 9 -tetrahydrocannabinol (Δ 9 -THC) 1 . Here we report two …

High-accuracy ab initio folding has remained an elusive objective despite decades of effort.
To explore the folding landscape of villin headpiece subdomain HP35, we conducted two …

Lipidic cubic phases (LCPs) have emerged as successful matrixes for the crystallization of
membrane proteins. Moreover, the viscous LCP also provides a highly effective delivery …

Conventional chemotherapy is the main treatment for cancer and benefits patients in the
form of decreased relapse and metastasis and longer overall survival. However, as the target …

Advances in deep learning have greatly improved structure prediction of molecules. However,
many macroscopic observations that are important for real-world applications are not …