Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction…

Background Single-cell transcriptomics is rapidly advancing our understanding of the
cellular composition of complex tissues and organisms. A major limitation in most analysis …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology 1 , 2 . Expression quantitative trait loci (eQTLs) help to explain the …

The Para rubber tree (Hevea brasiliensis) is an economically important tropical tree species
that produces natural rubber, an essential industrial raw material. Here we present a high-…

Background Cells can be primed by external stimuli to obtain a long-term epigenetic memory.
We hypothesize that long-term exposure to elevated blood lipids can prime circulating …

Parental epigenomes are established during gametogenesis. While they are largely reset
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA)
pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 …

We tested whether DNA-methylation profiles account for inter-individual variation in body
mass index (BMI) and height and whether they predict these phenotypes over and above …