The antioxidant tempol reduces obesity in mice. Here we show that tempol alters the gut
microbiome by preferentially reducing the genus Lactobacillus and its bile salt hydrolase (BSH) …

Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a
stable latent reservoir 1 , 2 , primarily in resting memory CD4 + T cells 3 , 4 . This reservoir …

Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat HCC…

Despite antiretroviral therapy, HIV-1 persists in memory CD4 + T cells, creating a barrier to
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant. Using …

Genes expressed under circadian-clock control are found in organisms ranging from
prokaryotes to humans. In Drosophila melanogaster, the period (per) gene, which is required for …

Lactylation was initially discovered on human histones. Given its nascence, its occurrence
on nonhistone proteins and downstream functional consequences remain elusive. Here we …

Gut microbial metabolism is intimately coupled with host health and disease. Aromatic
amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may …

Cholestasis is a common complication of sepsis, and the increased plasma levels of bile
acids are predictive of sepsis-associated mortality. However, the exact mechanism by which …

B-type lamins, the major components of the nuclear lamina, are believed to be essential for
cell proliferation and survival. We found that mouse embryonic stem cells (ESCs) do not …

Gut microbiome disturbances have been widely implicated in major depressive disorder (MDD),
although the identity of causal microbial species and the underlying mechanisms are yet …