An efficient, generalizable method for genome-wide mapping of single-cell histone modifications
or chromatin-binding proteins is lacking. Here, we develop CoBATCH, combinatorial …

Deciphering mechanisms in cell-fate decisions requires single-cell holistic reconstructions of
multidimensional epigenomic states in transcriptional regulation. Here we develop CoTECH…

Single-cell measurement of chromatin states, including histone modifications and non-histone
protein binding, remains challenging. Here, we present a low-cost, efficient, simultaneous …

A ratiometric fluorescence probe, NClO, for the rapid and selective detection of HClO had
been designed and synthesized based on a 1,8-naphthalimide derivative. Probe NClO …

By introducing the tetrahydroquinoxaline group as the electron donor to enhance intramolecular
charge transfer effect, we deliberately designed a coumarin derivative, TQC-HClO, to …

Mechanical forces are known to be important in mammalian blastocyst formation; however,
due to limited tools, specific force inputs and how they relay to first cell fate control of inner …

Rationale: We hypothesized that the differentiation processes of cardiac progenitor cell (CP)
from first and second heart fields (FHF and SHF) may undergo the unique instructive gene …

As two important reactive oxygen species, hydrogen peroxide (H 2 O 2 ) and hypochlorous
acid (HClO) play vital roles in many physiological and pathological processes. However, the …

In this work, we presented a fluorescent probe (MCQ-DNBS) for selective and sensitive
detection of biothiols based on a methylated chromenoquinoline (MCQ) derivative. Probe MCQ-…

Hydrogen sulfide (H2S), a critical endogenous signaling molecule, is widely involved in
many physiological processes. Endoplasmic reticulum, an important organelle with a sac-like …