[HTML][HTML] Comparison of nonhuman primates identified the suitable model for COVID-19

…, X Qian, H Li, S Zhao, J Li, H Wang, H Long… - Signal transduction and …, 2020 - nature.com
Identification of a suitable nonhuman primate (NHP) model of COVID-19 remains
challenging. Here, we characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

L Jiao, Y Yang, W Yu, Y Zhao, H Long, J Gao… - Signal transduction and …, 2021 - nature.com
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism
of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of …

Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates

…, B Zhang, W Yu, Z Lu, Y Pu, Y Zhang, H Long… - Nature medicine, 2022 - nature.com
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for
diabetes treatment 1 , 2 . However, this therapeutic strategy has not been systematically …

[HTML][HTML] Susceptibility of tree shrew to SARS-CoV-2 infection

…, D Kuang, J Xu, M Yang, C Ma, S Zhao, J Li, H Long… - Scientific reports, 2020 - nature.com
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic
event in the world, it has not only caused huge economic losses, but also a serious threat to …

The gastrointestinal tract is an alternative route for SARS-CoV-2 infection in a nonhuman primate model

…, H Wang, Y Yang, W Yu, J Wang, J Yang, H Long… - Gastroenterology, 2021 - Elsevier
Background & Aims Gastrointestinal (GI) manifestations have been increasingly reported in
patients with coronavirus disease 2019 (COVID-19). However, the roles of the GI tract in …

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

…, J Xu, X Qian, H Li, S Zhao, J Li, H Wang, H Long… - BioRxiv, 2020 - biorxiv.org
COVID-19, caused by SARS-CoV-2 infection, has recently been announced as a pandemic
all over the world. Plenty of diagnostic, preventive and therapeutic knowledges have been …

Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets

…, J Zhan, S Wu, Y Jiang, Z Lu, S Sun, Y Shi, H Long… - Nature …, 2023 - nature.com
Human pluripotent stem cell-derived islets (hPSC islets) are a promising alternative to primary
human islets for the treatment of insulin-deficient diabetes. We previously demonstrated …

SARS‐CoV‐2 Omicron (B. 1.1. 529) infection in rhesus macaques, hamsters, and BALB/c mice with severe lung histopathological damage

…, D Wu, Z Luo, J Gao, D Kuang, H Long… - Journal of Medical …, 2023 - Wiley Online Library
Since the first SARS‐CoV‐2 outbreak in late 2019, the SARS‐CoV‐2 genome has harbored
multiple mutations, especially spike protein mutations. The currently fast‐spreading Omicron …

A novel neutralizing antibody specific to the DE loop of VP1 can inhibit EV-D68 infection in mice

…, Z Yang, H Li, H Fan, X Huang, H Long… - The Journal of …, 2018 - journals.aai.org
Enterovirus D68 (EV-D68) belongs to the picornavirus family and was first isolated in CA,
USA, in 1962. EV-D68 can cause severe cranial nerve system damage such as flaccid …

[HTML][HTML] Nasal mucosa exploited by SARS-CoV-2 for replicating and shedding during reinfection

…, J Yang, J Zhou, F Yang, Y Chen, Y Zuo, Q Lai, H Long… - Viruses, 2022 - mdpi.com
… JY and HL (Haiting Long) participated in the histopathology experiments. JZ participated
in the ultrathin section TEM detection. HS, YC, YZ (Yuanyuan Zuo) and QL participated in …