Osteoporosis is the most common chronic metabolic bone disease. It has been estimated
that more than 10 million people in the United States and 200 million men and women …

STUDY QUESTION Is the decreased natural killer (NK) cell cytolytic activity in the peritoneal
fluid (PF) of endometriosis patients due to primary cytokine activity? SUMMARY ANSWER …

Natural killer (NK) cells play important roles in immune surveillance. However, the tumor
microenvironment suppresses NK cell function and allows cancer cells to evade immune …

Reactive oxygen species (ROS) are critical determinants of the fate of hematopoietic stem
cells (HSCs) and hematopoiesis. Thioredoxin-interacting protein (TXNIP), which is induced by …

Macrophage migration inhibitory factor (MIF) is a potent modulator of the p53 signaling pathway,
but the molecular mechanisms of the effect of MIF on p53 function have so far remained …

Higher-order chromatin structure and DNA methylation are implicated in multiple developmental
processes, but their relationship to cell state is unknown. Here, we find that large (>7.3 …

Rho GTPases play central roles in numerous cellular processes, including cell motility, cell
polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell …

Background: Immature platelet fraction (IPF,%) is a measure of reticulated platelets (RPs),
which represents the state of thrombopoiesis. The IPF is obtained from an automated …

Ginsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient
of Panax ginseng. However, its role in the inflammasome activation process remains …

Many elderly people suffer from hematological diseases known to be highly age-dependent.
Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells …