Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only ∼1% of eukaryotic TFs. Broadly sampling DNA-binding domain (DBD…

RNA-binding proteins are key regulators of gene expression, yet only a small fraction have
been functionally characterized. Here we report a systematic analysis of the RNA motifs …

INTRODUCTION Advancing whole-genome precision medicine requires understanding
how gene expression is altered by genetic variants, especially those that are far outside of …

Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative human
transcription factors. However, for most C2H2-ZF proteins it is unknown whether they even bind …

Cancer stem cells are critical for cancer initiation, development, and treatment resistance.
Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is …

Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …

Due to the depletion of fossil fuels and their environmental issues, it is necessary to find
energy resources which are renewable. Algal biomass becomes promising feedstock for bio-fuel …

Decoding post-transcriptional regulatory programs in RNA is a critical step towards the
larger goal of developing predictive dynamical models of cellular behaviour. Despite recent …

C2H2 zinc finger proteins represent the largest and most enigmatic class of human transcription
factors. Their C2H2-ZF arrays are highly variable, indicating that most will have unique …

… Author links open overlay panel Pouria Jandaghi 1 2 3 , Hamed S. Najafabadi 2 3 , Andrea
S. Bauer 1 , Andreas I. Papadakis 4 5 , Matteo Fassan 6 , Anita Hall 5 7 , Anie Monast 5 , …