User profiles for Han-Chung Wu

Han-Chung Wu

Institute of Cellular and Organismic Biology, Academia Sinica
Verified email at gate.sinica.edu.tw
Cited by 8585

[HTML][HTML] Development of therapeutic antibodies for the treatment of diseases

…, IJ Liu, CC Lee, HZ Tsai, HJ Li, HC Wu - Journal of biomedical …, 2020 - Springer
It has been more than three decades since the first monoclonal antibody was approved by
the United States Food and Drug Administration (US FDA) in 1986, and during this time, …

[HTML][HTML] Advancement and applications of peptide phage display technology in biomedical science

CH Wu, IJ Liu, RM Lu, HC Wu - Journal of biomedical science, 2016 - Springer
Combinatorial phage library is a powerful research tool for high-throughput screening of
protein interactions. Of all available molecular display techniques, phage display has proven to …

Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly …

…, SR Lin, CL Kao, HP Hu, CC King, HC Wu… - Journal of …, 2008 - Am Soc Microbiol
The antibody response to the envelope (E) glycoprotein of dengue virus (DENV) is known to
play a critical role in both protection from and enhancement of disease, especially after …

[HTML][HTML] A critical overview of current progress for COVID-19: development of vaccines, antiviral drugs, and therapeutic antibodies

…, IJ Lee, WS Li, HP Hsieh, MH Tao, HC Wu - Journal of biomedical …, 2022 - Springer
The novel coronavirus disease (COVID-19) pandemic remains a global public health crisis,
presenting a broad range of challenges. To help address some of the main problems, the …

[HTML][HTML] Effect of SARS-CoV-2 B. 1.1. 7 mutations on spike protein structure and function

…, HC Tso, MR Ho, WY Chen, HT Lin, HC Wu… - Nature structural & …, 2021 - nature.com
The B.1.1.7 variant of SARS-CoV-2 first detected in the UK harbors amino-acid substitutions
and deletions in the spike protein that potentially enhance host angiotensin conversion …

High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis

WK Wang, DY Chao, CL Kao, HC Wu, YC Liu, CM Li… - Virology, 2003 - Elsevier
Studies of the pathogenesis of dengue hemorrhagic fever (DHF), a potentially life-threatening
disease, have revealed the importance of initial high levels of virus replication. However, …

Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery

A Lo, CT Lin, HC Wu - Molecular cancer therapeutics, 2008 - AACR
Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide. Novel
treatment strategies derived from increased knowledge of molecular oncology are constantly …

[PDF][PDF] Targeted therapy for cancer

HC Wu, DK Chang, CT Huang - J Cancer Mol, 2006 - researchgate.net
The first description of cancer is found in an Egyptian papyrus and dates back to approximately
1600 BC. It was regarded as an incurable disease until the nineteenth century, when …

[HTML][HTML] Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

…, SH Ko, FY Ke, KH Liang, TY Hsieh, HC Wu - Journal of Biomedical …, 2022 - Springer
The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis
that demands the timely creation of new therapeutics and viral detection. Owing to their high …

Peptide-mediated targeting to tumor blood vessels of lung cancer for drug delivery

TY Lee, CT Lin, SY Kuo, DK Chang, HC Wu - Cancer research, 2007 - AACR
Antiangiogenesis therapies for the treatment of cancers hold the promise of high efficacy and
low toxicity. In vivo phage display was used to identify peptides specifically targeting tumor …