Despite initial promise, the development of type 4 phosphodiesterase (PDE4) inhibitors as
antidepressants has not advanced significantly. This is due to an incomplete understanding of …

Phosphodiesterase-4 (PDE4) plays an important role in mediating memory via the control of
intracellular cAMP signaling; inhibition of PDE4 enhances memory. However, development …

Pharmacological inhibition of type 4 cyclic adenosine monophosphate (cAMP)-specific
phosphodiesterase (PDE4) produces antidepressant-like effects in animals; however, it is not …

Inhibition of phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic
AMP (cAMP), increases phosphorylation of the cAMP response element binding protein (…

Phosphodiesterase-4 (PDE4), one of eleven PDE enzyme families, specifically catalyzes
hydrolysis of cyclic AMP (cAMP); it has four subtypes (PDE4A-D) with at least 25 splice variants…

… Han-Ting Zhang Han-Ting Zhang … Han-Ting Zhang has received financial support for
his research from Memory Pharmaceuticals and Lundbeck Pharmaceuticals. …

Phosphodiesterase-4 (PDE4), an enzyme that catalyzes the hydrolysis of cyclic AMP and
plays a critical role in controlling its intracellular concentration, has been implicated in …

Although cognitive dysfunction manifested by severe memory and attention deficits has been
reported in up to 70% of cancer patients undergoing chemotherapy, the mechanisms of this …

Rolipram, a selective inhibitor of type 4 cyclic AMP phosphodiesterase (PDE4), completely
reversed the amnesic effects of MK-801 on working and reference memory (F[4,64] = 11.10; p …

Introduction: The second messengers cAMP and cGMP mediate fundamental aspects of
brain function relevant to memory, learning, and cognitive functions. Consequently, cyclic …