Tau is a microtubule-associated protein (MAP) responsible for controlling the stabilization of
microtubules in neurons. Tau function is regulated by phosphorylation. However, in some …

Tau is a neuronal, microtubule-associated protein responsible for controlling the stabilization
of microtubules in neurons. Tau function is regulated by phosphorylation, but in some …

Target deconvolution of small molecule hits from phenotypic screens presents a major
challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling …

Studies have suggested an important connection between epilepsy and Alzheimer’s disease
(AD), mostly due to the high number of patients diagnosed with AD who develop epileptic …

Background: Marfan syndrome, caused by mutations in the gene for fibrillin-1, leads to
thoracic aortic aneurysms (TAAs). Phenotypic modulation of vascular smooth muscle cells (SMCs) …

Atherosclerosis is a chronic inflammatory disease that originates at regions of arteries exposed
to disturbances in fluid flow and results in progressive plaque formation in those areas. …

Shear stress is a frictional drag generated by the flow of fluid, such as blood or interstitial fluid,
and plays a critical role in regulating cellular gene expression and functional phenotype. …

… To my sister, Hannah, for motiving me to work harder every day. I would like to thank my
wonderful partner and best friend, Ben, who has shown me unwavering love and support as I’ve …

Chronic lymphocytic leukemia (CLL) is characterized by an acquired immune dysfunction.
CLL cells affect the phenotype and function of the entire spectrum of innate and adaptive …

Objective: To present the scientific contributions of Georges Marinesco (1863–1938) and
place his achievements within the context of early neuropathology research. Background: …