CRISPR-Cas9 viability screens are increasingly performed at a genome-wide scale across
large panels of cell lines to identify new therapeutic targets for precision cancer therapy. …

Genome-scale CRISPR-Cas9 viability screens performed in cancer cell lines provide a
systematic approach to identify cancer dependencies and new therapeutic targets. As multiple …

Purpose Internationally adopted variant interpretation guidelines from the American College
of Medical Genetics and Genomics (ACMG) are generic and require disease-specific …

Using 11 proteomics datasets, mostly available through the PRIDE database, we assembled
a reference expression map for 191 cancer cell lines and 246 clinical tumour samples, …

Selecting appropriate cancer models is a key prerequisite for maximizing translational
potential and clinical relevance of in vitro oncology studies. We developed CELLector: an R …

There is increasing evidence that stromal myofibroblasts play a key role in the tumour
development however, the mechanisms by which they become reprogrammed to assist in cancer …

Although hypoxia is known to contribute to several aspects of tumour progression, relatively
little is known about the effects of hypoxia on cancer-associated myofibroblasts (CAMs), or …

The nature of biological networks still brings challenges related to computational complexity,
interpretable results and statistical significance. Recent work proposes a new method that …

Purpose Internationally-adopted variant interpretation guidelines from the American
College of Medical Genetics and Genomics (ACMG) are generic and require disease-specific …

In recent years it has become increasingly apparent that tumour development and metastasis
are not simply driven by mutations within cancer cells. Factors produced by stromal …