Endoplasmic reticulum stress resulting from abnormal folding of newly synthesized proteins
impairs metabolism, transcriptional regulation, and gene expression, and it is a key …

With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an
ideal drug or drug combination should target at least several key pathogenetic mechanisms. …

Background Peroxynitrite, a product of the reaction of superoxide with nitric oxide, causes
oxidative stress with concomitant inactivation of enzymes, poly(ADP‐ribosylation), …

The purpose of this study was to determine the effect of supplementing the diet of a mouse
model of type 2 diabetes with menhaden (fish) oil or daily treatment with resolvin D1 on …

This study evaluated the role of poly(ADP-ribose) polymerase (PARP) in systemic oxidative
stress and 4-hydoxynonenal adduct accumulation in diabetic peripheral neuropathy. Control …

We determined the impact diet‐induced obesity ( DIO ) and types 1 and 2 diabetes have on
peripheral neuropathy with emphasis on corneal nerve structural changes in C57Bl / 6J mice…

This study evaluated poly(ADP-ribose) polymerase (PARP) inhibition as a new therapeutic
approach for peripheral diabetic neuropathy using clinically relevant animal model and …

We sought to determine the impact that duration of hyperglycemia and control has on corneal
nerve fiber density in relation to standard diabetic neuropathy endpoints. Control and …

This study evaluated the role of 12/15-lipoxygenase, which converts arachidonic acid to 12(S)-
and 15(S)-hydroxyeicosatetraenoic acids, in nitrosative stress in the peripheral nervous …

Aims/Introduction Peripheral neuropathy is a common complication of diabetes and also
occurs in 30% of human obese individuals with impaired glucose tolerance. Even though …