Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived
precursors that are thought to undergo apoptosis once resorption is …

Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic
burden, yet no drugs are available that prevent disease onset or progression. Here, we …

This study advances the understanding of therapy-induced dormancy with potential clinical
implications for breast cancer. Estrogen receptor-positive breast cancer cells adapt to …

Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone
mineral density (BMD). We undertook a comprehensive assessment of human genetic …

The nuclear factor I/X (NFIX) gene encodes a ubiquitously expressed transcription factor
whose mutations lead to two allelic disorders characterized by developmental, skeletal, and …

Background Thiopurines are widely used for maintenance of remission in Crohn's disease (CD).
Published data report >50% of patients stop thiopurines due to therapeutic failure, …

In the version of this article initially published, in Fig. 5a, the data in the right column of ‘DAAM2
gRNA1’were incorrectly plotted as circles indicating ‘untreated’rather than as squares …

Previously representing the threat of infection, invasion and the possibility of an internal Other,
the werewolf, traditionally male, has recently been joined by a subgroup of wolf-women in …

Introduction Biologic drugs are effective treatments in IBD, the use of therapeutic drug
monitoring (TDM) is rapidly becoming part of routine clinical practice. The American …