The integrity of genomes is constantly threatened by problems encountered by the replication
fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication …

Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance
remains unclear, although they have been associated with more aggressive tumours. Here we …

Cell-in-cell (CIC) is a term used to describe the presence of one, usually living, cell inside
another cell that is typically considered non-phagocytic. Examples of this include tumour cells …

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …

Drug repurposing is a cost-effective means of targeting new therapies for cancer. We have
examined the effects of the repurposed drugs, bezafibrate, medroxyprogesterone acetate and …

Mammalian DNA replication employs several RecQ DNA helicases to orchestrate the
faithful duplication of genetic information. Helicase function is often coupled to the activity of …

We propose Dirichlet Process mixtures of Generalized Linear Models (DP-GLM), a new class
of methods for nonparametric regression. Given a data set of input-response pairs, the DP-…

Aicardi–Goutières syndrome is an inflammatory disease occurring due to mutations in any
of TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR or IFIH1. We report on …

Abstract Changes in the mountain cryosphere impact the water security of downstream
societies and the resilience of water-dependent ecosystems and their services. However, …

Since the introduction of DIALANG, technological advances have made possible timely,
dynamic, and multi-agent implementation of language assessment and feedback for learners. In …