[PDF][PDF] Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage

A Götz, N Mylonas, P Högel, M Silber, H Heinel… - Biophysical journal, 2019 - cell.com
Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is
implicated in Alzheimer's disease pathogenesis. Biophysical data have suggested that the N…

Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes

…, E Winkler, G Basset, H Heinel… - ACS Chemical …, 2018 - ACS Publications
Bexarotene is a pleiotropic molecule that has been proposed as an amyloid-β (Aβ)-lowering
drug for the treatment of Alzheimer’s disease (AD). It acts by upregulation of an …

Stabilization/destabilization of the APP transmembrane domain by mutations in the di-glycine hinge alter helical structure and dynamics, and impair cleavage by γ …

A Götz, N Mylonas, P Högel, M Silber, H Heinel… - bioRxiv, 2018 - biorxiv.org
γ-Secretase is a pivotal intramembrane protease that is involved in the generation of toxic
Alzheimers disease-associated peptides from the γ-amyloid precursor protein C-terminal …

[HTML][HTML] Binding of Bexarotene to the Amyloid Precursor Protein Transmembrane Domain in Liposomes Alters its α-Helical Conformation but Inhibits γ-Secretase Non …

…, HA Scheidt, E Winkler, G Basset, H Heinel… - ACS chemical …, 2018 - ncbi.nlm.nih.gov
Bexarotene is a pleiotropic molecule that has been proposed as an amyloid-β (Aβ)-lowering
drug for the treatment of Alzheimers disease (AD). It acts by upregulation of an …

Elementary school teachers and the struggle against social democracy in wilhelmine Germany

M Lamberti - History of Education Quarterly, 1992 - cambridge.org
Even before the Reichstag defeated the renewal of the law banning the Social Democratic
party in January 1890, Emperor William II was ready to discard Bismarck's policy of …

Prenatal diagnostics in TESA/PESA pregnancies in Denmark 1995-2007: a shift from invasive procedures to nuchal translucency examination

J Fedder, K Erb, P Humaidan, S Maigaard… - Systems Biology in …, 2011 - Taylor & Francis
Evidently, children born after intracytoplasmic sperm injection (ICSI) are at an increased risk
of having sex chromosomal abnormalities. Here we evaluate the change in methods used …

[PDF][PDF] Konrad Kunze

K Dräger - 34e année (2016) n 2 (juin), 2016 - atilf.fr
Die deutschen Sprachinseln in Polen sind heutzutage in diesen 2010 er Jahren in Auflösung
begriffen. Auf der einen Seite können wir von den Sprachinseln sprechen, die es vor dem …

Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures

K Dinkel, FS Dhabhar… - Proceedings of the …, 2004 - National Acad Sciences
Many neurological insults and neurodegenerative disorders are accompanied by an acute
inflammatory reaction that can contribute to neuronal damage. This inflammation involves …

The End of the Dream of the'Other Germany': The'German Question'in West German Letters

K Bullivant - European Cultures, 1870 - degruyter.com
After a brief survey of the dominant attitudes amongst West German writers to the" German
Question" since 1945, this essay concentrates in detail on statements made in the second half …

List of Prophets (1517–1800)

J Beyer - Lay Prophets in Lutheran Europe (c. 1550–1700), 2017 - brill.com
This bibliographical list attempts to be as complete as possible but could doubtless be
enlarged with many cases preserved in archives or published in regional journals. It could also …