[PDF][PDF] Modulating hinge flexibility in the APP transmembrane domain alters γ-secretase cleavage
A Götz, N Mylonas, P Högel, M Silber, H Heinel… - Biophysical journal, 2019 - cell.com
Intramembrane cleavage of the β-amyloid precursor protein C99 substrate by γ-secretase is
implicated in Alzheimer's disease pathogenesis. Biophysical data have suggested that the N…
implicated in Alzheimer's disease pathogenesis. Biophysical data have suggested that the N…
Bexarotene binds to the amyloid precursor protein transmembrane domain, alters its α-helical conformation, and inhibits γ-secretase nonselectively in liposomes
…, E Winkler, G Basset, H Heinel… - ACS Chemical …, 2018 - ACS Publications
Bexarotene is a pleiotropic molecule that has been proposed as an amyloid-β (Aβ)-lowering
drug for the treatment of Alzheimer’s disease (AD). It acts by upregulation of an …
drug for the treatment of Alzheimer’s disease (AD). It acts by upregulation of an …
Stabilization/destabilization of the APP transmembrane domain by mutations in the di-glycine hinge alter helical structure and dynamics, and impair cleavage by γ …
A Götz, N Mylonas, P Högel, M Silber, H Heinel… - bioRxiv, 2018 - biorxiv.org
γ-Secretase is a pivotal intramembrane protease that is involved in the generation of toxic
Alzheimers disease-associated peptides from the γ-amyloid precursor protein C-terminal …
Alzheimers disease-associated peptides from the γ-amyloid precursor protein C-terminal …
[HTML][HTML] Binding of Bexarotene to the Amyloid Precursor Protein Transmembrane Domain in Liposomes Alters its α-Helical Conformation but Inhibits γ-Secretase Non …
…, HA Scheidt, E Winkler, G Basset, H Heinel… - ACS chemical …, 2018 - ncbi.nlm.nih.gov
Bexarotene is a pleiotropic molecule that has been proposed as an amyloid-β (Aβ)-lowering
drug for the treatment of Alzheimers disease (AD). It acts by upregulation of an …
drug for the treatment of Alzheimers disease (AD). It acts by upregulation of an …
Elementary school teachers and the struggle against social democracy in wilhelmine Germany
M Lamberti - History of Education Quarterly, 1992 - cambridge.org
Even before the Reichstag defeated the renewal of the law banning the Social Democratic
party in January 1890, Emperor William II was ready to discard Bismarck's policy of …
party in January 1890, Emperor William II was ready to discard Bismarck's policy of …
Prenatal diagnostics in TESA/PESA pregnancies in Denmark 1995-2007: a shift from invasive procedures to nuchal translucency examination
J Fedder, K Erb, P Humaidan, S Maigaard… - Systems Biology in …, 2011 - Taylor & Francis
Evidently, children born after intracytoplasmic sperm injection (ICSI) are at an increased risk
of having sex chromosomal abnormalities. Here we evaluate the change in methods used …
of having sex chromosomal abnormalities. Here we evaluate the change in methods used …
[PDF][PDF] Konrad Kunze
K Dräger - 34e année (2016) n 2 (juin), 2016 - atilf.fr
Die deutschen Sprachinseln in Polen sind heutzutage in diesen 2010 er Jahren in Auflösung
begriffen. Auf der einen Seite können wir von den Sprachinseln sprechen, die es vor dem …
begriffen. Auf der einen Seite können wir von den Sprachinseln sprechen, die es vor dem …
Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures
K Dinkel, FS Dhabhar… - Proceedings of the …, 2004 - National Acad Sciences
Many neurological insults and neurodegenerative disorders are accompanied by an acute
inflammatory reaction that can contribute to neuronal damage. This inflammation involves …
inflammatory reaction that can contribute to neuronal damage. This inflammation involves …
The End of the Dream of the'Other Germany': The'German Question'in West German Letters
K Bullivant - European Cultures, 1870 - degruyter.com
After a brief survey of the dominant attitudes amongst West German writers to the" German
Question" since 1945, this essay concentrates in detail on statements made in the second half …
Question" since 1945, this essay concentrates in detail on statements made in the second half …
List of Prophets (1517–1800)
J Beyer - Lay Prophets in Lutheran Europe (c. 1550–1700), 2017 - brill.com
This bibliographical list attempts to be as complete as possible but could doubtless be
enlarged with many cases preserved in archives or published in regional journals. It could also …
enlarged with many cases preserved in archives or published in regional journals. It could also …