The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique
population history accompanied by selection for novel and desirable traits. Here we perform a …

Epilepsy afflicts 1% of humans and 5% of dogs. We report a canine epilepsy mutation and
evidence for the existence of repeat-expansion disease outside humans. A canid-specific …

Rett syndrome is caused by mutations in the gene MECP2 in ∼80% of affected individuals.
We describe a previously unknown MeCP2 isoform. Mutations unique to this isoform and the …

Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and
monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify the …

A rural environment and farming lifestyle are known to provide protection against allergic
diseases. This protective effect is expected to be mediated via exposure to environmental …

The domestic dog offers a unique opportunity to explore the genetic basis of disease,
morphology and behaviour. Humans share many diseases with our canine companions, making …

Intense selective pressures applied over short evolutionary time have resulted in homogeneity
within, but substantial variation among, horse breeds. Utilizing this population structure, …

The unique canine breed structure makes dogs an excellent model for studying genetic
diseases. Within a dog breed, linkage disequilibrium is extensive 1 , 2 , enabling genome-wide …

The origin and evolution of the domestic dog remains a controversial question for the scientific
community, with basic aspects such as the place and date of origin, and the number of …

Congenital chloride diarrhea (CLD) is a recessively inherited disorder of intestinal
electrolyte absorption that involves, specifically, Cl − / HCO 3 − exchange. CLD is caused by …