The activation of mixed lineage kinase-like (MLKL) by receptor-interacting protein kinase-3 (RIPK3)
results in plasma membrane (PM) disruption and a form of regulated necrosis, called …

Klotho was discovered as an antiaging gene, and α-Klotho (Klotho) is expressed in multiple
tissues with a broad set of biologic functions. Membrane-bound Klotho binds fibroblast …

Background In vivo models of uremia are important tools to study numerous aspects of
acute and chronic kidney disease. Mouse models are pivotal because most genetically …

Klotho acts as a co-receptor for and dictates tissue specificity of circulating FGF23. FGF23
inhibits PTH secretion, and reduced Klotho abundance is considered a pathogenic factor in …

Objective— Hyperphosphatemia is a cardiovascular risk factor in patients with chronic kidney
disease. Relations of circulating calcium (Ca) and phosphorus (Pi) to long-term mortality …

Recent studies support a role for FGF23 and its co-receptor Klotho in cardiovascular
pathology, yet the underlying mechanisms remain largely elusive. Herein, we analyzed the …

Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of
phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D–…

Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone
disorder. In order to validate its potential as a predictor of vascular calcification, we explored …

Current studies suggest that short-term exposure of parathyroid glands to fibroblast growth
factor 23 (FGF23) reduces parathyroid hormone secretion. However, patients with chronic …

Diabetic kidney disease (DKD) is the most common cause of severe renal disease, and few
treatment options are available today that prevent the progressive loss of renal function. …