User profiles for Hans Clevers
Hans CleversHubrecht Institute - Utrecht Verified email at hubrecht.eu Cited by 263577 |
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have
recently demonstrated the presence of about six cycling Lgr5 + stem cells at the bottoms of …
recently demonstrated the presence of about six cycling Lgr5 + stem cells at the bottoms of …
Identification of stem cells in small intestine and colon by marker gene Lgr5
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently
believed that four to six crypt stem cells reside at the +4 position immediately above the …
believed that four to six crypt stem cells reside at the +4 position immediately above the …
[PDF][PDF] Modeling development and disease with organoids
H Clevers - Cell, 2016 - cell.com
Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect …
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect …
[HTML][HTML] Wnt/β-catenin signaling in development and disease
H Clevers - Cell, 2006 - cell.com
A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins that …
transduction cascade over the last two decades. Wnt genes encode small secreted proteins that …
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Homeostasis of self-renewing small intestinal crypts results from neutral competition between
Lgr5 stem cells, which are small cycling cells located at crypt bottoms 1 , 2 . Lgr5 stem cells …
Lgr5 stem cells, which are small cycling cells located at crypt bottoms 1 , 2 . Lgr5 stem cells …
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
…, A Pronk, J Van Gorp, PD Siersema, H Clevers - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: We previously established long-term culture conditions under which
single crypts or stem cells derived from mouse small intestine expand over long periods. …
single crypts or stem cells derived from mouse small intestine expand over long periods. …
SARS-CoV-2 productively infects human gut enterocytes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …
Wnt signalling in stem cells and cancer
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues,
activation of Wnt signalling has also been associated with cancer. This has raised the …
activation of Wnt signalling has also been associated with cancer. This has raised the …
Crypt stem cells as the cells-of-origin of intestinal cancer
Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous
polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a …
polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a …
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …