We report a comprehensive molecular characterization of pheochromocytomas and
paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/…

The biosynthesis of steroid hormones requires the coordinated expression of the enzymes
that comprise the pathways via which specific hormones are synthesized. These pathways …

Background Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE)
tumor without recognized morphologic heterogeneity. However, over 30 years ago we …

Context: Primary aldosteronism is a heterogeneous disease that includes both sporadic and
familial forms. A point mutation in the KCNJ5 gene is responsible for familial …

Patients with germline SDHD pathogenic variants (encoding succinate dehydrogenase
subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck …

… Hans K Ghayee Hans K Ghayee Department of Medicine, Division of Endocrinology,
University of Florida College of Medicine and Malcom Randall VA Medical Center, Gainesville, …

Objective: The objective of this Disease State Clinical Review is to provide clinicians with a
practical approach to the evaluation of incidentally discovered adrenal masses. Methods: A …

Pheochromocytomas (PCCs) are rare neuroendocrine tumors. About 80% to 85% of these
cancers arise from chromaffin cells residing in the adrenal medulla. The remaining 15% to 20…

Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with
severe catecholamine-induced morbidities. Surgical removal is often curative. However, …

Background Pheochromocytoma and paraganglioma (PPGL) are neuroendocrine tumors with
frequent mutations in genes linked to the tricarboxylic acid cycle. However, no pathogenic …