DieWeltgesundheitsorganisation (WHO) bezeichnet die Adipositas als eines der
offensichtlichsten, aber am meisten vernachlässigten Probleme der öffentlichen Gesundheit und …

Environmental factors such as tobacco smoking may have long-lasting effects on DNA
methylation patterns, which might lead to changes in gene expression and in a broader context to …

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a strong
genetic background. One of the characteristic features of AD and causative factor for the …

BACKGROUND: The discovery of filaggrin (FLG) null mutations as a major risk factor for
eczema represents a milestone toward the understanding of an important mechanism in this …

BACKGROUND: Mutations in the filaggrin gene (FLG) have been shown to play a significant
role in ichthyosis vulgaris and eczema, 2 common chronic skin diseases. However, their …

Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the
same individuals 1 , partly because of a shared genetic origin 2 , 3 , 4 . To identify shared risk …

We conducted a genome-wide association study in 939 individuals with atopic dermatitis
and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs …

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …

Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …

High levels of serum IgE are considered markers of parasite and helminth exposure. In addition,
they are associated with allergic disorders, play a key role in anti-tumoral defence, and …