[HTML][HTML] Understanding the mechanistic contribution of herbal extracts in compound kushen injection with transcriptome analysis

H Shen, Z Qu, Y Harata-Lee, TN Aung, J Cui… - Frontiers in …, 2019 - frontiersin.org
Herbal compatibility is the knowledge of which herbs to combine in traditional Chinese
medicine (TCM) formulations. The lack of understanding of herbal compatibility is one of the key …

[HTML][HTML] Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection

J Cui, Z Qu, Y Harata-Lee, T Nwe Aung, H Shen… - BMC cancer, 2019 - Springer
Background In this report we examine candidate pathways perturbed by Compound Kushen
Injection (CKI), a Traditional Chinese Medicine (TCM) that we have previously shown to …

Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins

M Zhao, W Xu, H Shen, P Shen, J Zhang… - … of pharmaceutical and …, 2017 - Elsevier
Ophiopogon japonicus (Linn. f.) Ker-Gawl (O. japonicas), mainly cultivated in Sichuan and
Zhejiang province in China, has different bioactive components and therefore their …

[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: An IUPHAR positional review

…, AMC Pimenta, JAA Parra, Z Qu, H Shen… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …

Quantitative structure–ion intensity relationship strategy to the prediction of absolute levels without authentic standards

L Wu, Y Wu, H Shen, P Gong, L Cao, G Wang… - Analytica Chimica Acta, 2013 - Elsevier
The lack of authentic standards represents a major bottleneck in the quantitative analysis of
complex samples. Here we propose a quantitative structure and ionization intensity …

An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures

L Wu, P Gong, Y Wu, K Liao, H Shen, Q Qi, H Liu… - … of Chromatography A, 2013 - Elsevier
Identification of nontarget compounds in complex mixtures is of significant importance in
various scientific fields. On the basis of the universal property that the compounds in complex …

[HTML][HTML] The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms

J Cui, Z Qu, Y Harata-Lee, H Shen, TN Aung, W Wang… - PloS one, 2020 - journals.plos.org
Traditional Chinese Medicine (TCM) preparations are often extracts of single or multiple
herbs containing hundreds of compounds, and hence it has been difficult to study their …

[HTML][HTML] A new Strategy for identifying Mechanisms of Drug-drug interaction Using transcriptome Analysis: compound Kushen injection as a proof of principle

H Shen, Z Qu, Y Harata-Lee, J Cui, TN Aung… - Scientific Reports, 2019 - nature.com
Drug-drug interactions (DDIs), especially with herbal medicines, are complex, making it difficult
to identify potential molecular mechanisms and targets. We introduce a workflow to carry …

[HTML][HTML] ACLY facilitates colon cancer cell metastasis by CTNNB1

J Wen, X Min, M Shen, Q Hua, Y Han, L Zhao… - Journal of Experimental …, 2019 - Springer
Background Colon cancer is the second leading cancer worldwide. Recurrent disease and
chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. …

Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

…, JP Leshock, S Qu, CJ Su, W Shen… - Proceedings of the …, 2019 - National Acad Sciences
Pharmacology and optogenetics are widely used in neuroscience research to study the central
and peripheral nervous systems. While both approaches allow for sophisticated studies …