[HTML][HTML] Understanding the mechanistic contribution of herbal extracts in compound kushen injection with transcriptome analysis
Herbal compatibility is the knowledge of which herbs to combine in traditional Chinese
medicine (TCM) formulations. The lack of understanding of herbal compatibility is one of the key …
medicine (TCM) formulations. The lack of understanding of herbal compatibility is one of the key …
[HTML][HTML] Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection
J Cui, Z Qu, Y Harata-Lee, T Nwe Aung, H Shen… - BMC cancer, 2019 - Springer
Background In this report we examine candidate pathways perturbed by Compound Kushen
Injection (CKI), a Traditional Chinese Medicine (TCM) that we have previously shown to …
Injection (CKI), a Traditional Chinese Medicine (TCM) that we have previously shown to …
Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins
M Zhao, W Xu, H Shen, P Shen, J Zhang… - … of pharmaceutical and …, 2017 - Elsevier
Ophiopogon japonicus (Linn. f.) Ker-Gawl (O. japonicas), mainly cultivated in Sichuan and
Zhejiang province in China, has different bioactive components and therefore their …
Zhejiang province in China, has different bioactive components and therefore their …
[HTML][HTML] Future directions for the discovery of natural product-derived immunomodulating drugs: An IUPHAR positional review
…, AMC Pimenta, JAA Parra, Z Qu, H Shen… - Pharmacological …, 2022 - Elsevier
Drug discovery from natural sources is going through a renaissance, having spent many
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …
decades in the shadow of synthetic molecule drug discovery, despite the fact that natural …
Quantitative structure–ion intensity relationship strategy to the prediction of absolute levels without authentic standards
L Wu, Y Wu, H Shen, P Gong, L Cao, G Wang… - Analytica Chimica Acta, 2013 - Elsevier
The lack of authentic standards represents a major bottleneck in the quantitative analysis of
complex samples. Here we propose a quantitative structure and ionization intensity …
complex samples. Here we propose a quantitative structure and ionization intensity …
An integral strategy toward the rapid identification of analogous nontarget compounds from complex mixtures
L Wu, P Gong, Y Wu, K Liao, H Shen, Q Qi, H Liu… - … of Chromatography A, 2013 - Elsevier
Identification of nontarget compounds in complex mixtures is of significant importance in
various scientific fields. On the basis of the universal property that the compounds in complex …
various scientific fields. On the basis of the universal property that the compounds in complex …
[HTML][HTML] The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms
Traditional Chinese Medicine (TCM) preparations are often extracts of single or multiple
herbs containing hundreds of compounds, and hence it has been difficult to study their …
herbs containing hundreds of compounds, and hence it has been difficult to study their …
[HTML][HTML] A new Strategy for identifying Mechanisms of Drug-drug interaction Using transcriptome Analysis: compound Kushen injection as a proof of principle
Drug-drug interactions (DDIs), especially with herbal medicines, are complex, making it difficult
to identify potential molecular mechanisms and targets. We introduce a workflow to carry …
to identify potential molecular mechanisms and targets. We introduce a workflow to carry …
[HTML][HTML] ACLY facilitates colon cancer cell metastasis by CTNNB1
J Wen, X Min, M Shen, Q Hua, Y Han, L Zhao… - Journal of Experimental …, 2019 - Springer
Background Colon cancer is the second leading cancer worldwide. Recurrent disease and
chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. …
chemotherapeutic drug resistance are very common in the advanced stage of colon cancer. …
Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics
Pharmacology and optogenetics are widely used in neuroscience research to study the central
and peripheral nervous systems. While both approaches allow for sophisticated studies …
and peripheral nervous systems. While both approaches allow for sophisticated studies …