Gene-based therapy is the intentional modulation of gene expression in specific cells to
treat pathological conditions. This modulation is accomplished by introducing exogenous …

Edge computing has great potential to address the challenges in mobile vehicular networks
by transferring partial storage and computing functions to network edges. However, it is still …

Efficient genome editing with Cas9–sgRNA in vivo has required the use of viral delivery
systems, which have limitations for clinical applications. Translational efforts to develop other …

With the development of 4G/5G technology and smart devices, more and more users begin
to play games via their mobile devices. As a promising way to enable users to play any …

Due to the flexibility in 3-D space and high probability of line-of-sight (LoS) in air-to-ground
communications, unmanned aerial vehicles (UAVs) have been considered as means to …

The draft genome of the pear (Pyrus bretschneideri) using a combination of BAC-by-BAC and
next-generation sequencing is reported. A 512.0-Mb sequence corresponding to 97.1% of …

We demonstrate CRISPR-Cas9–mediated correction of a Fah mutation in hepatocytes in a
mouse model of the human disease hereditary tyrosinemia. Delivery of components of the …

With the explosive network data due to the advanced development of the Internet of Things (IoT),
the demand for multiparty computation is increasing. In addition, with the advent of …

The combination of Cas9, guide RNA and repair template DNA can induce precise gene
editing and the correction of genetic diseases in adult mammals. However, clinical …

The study of cancer genes in mouse models has traditionally relied on genetically-engineered
strains made via transgenesis or gene targeting in embryonic stem cells 1 . Here we …