Naturally occurring cell death (NOCD) is a prominent feature of the developing nervous
system. During this process, neurons express bcl-2, a major regulator of cell death whose …

Accumulation of misfolded proteins and alterations in Ca 2+ homeostasis in the
endoplasmic reticulum (ER) causes ER stress and leads to cell death. However, the signal-transducing …

Macroautophagy (hereafter autophagy) is a key pathway in neurodegeneration. Despite
protective actions, autophagy may contribute to neuron demise when dysregulated. Here we …

Glia synthesize, package, and secrete several species of matrix proteases, including the
gelatinases (pro-)MMP-2 and (pro-)MMP-9. In appropriate settings (eg, experimental ischemia), …

Hemorrhage and edema accompany evolving brain tissue injury after ischemic stroke. In
patients, these events have been associated with metalloproteinase (MMP)-9 in plasma. Both …

Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's
disease (SAD) is difficult due to genetic and environmental heterogeneity in the human …

Background The familial and sporadic forms of Alzheimer's disease (AD) have an identical
pathology with a severe disparity in the time of onset [1] . The pathological similarity suggests …

In vitro, the overexpression of the bcl-2 protooncogene in cultured neurons has been shown
to prevent apoptosis induced by neurotrophic factor deprivation. We have generated …

One of the most important pathological features of Alzheimer's disease (AD) is extracellular
senile plaques, whose major component is amyloid‐β peptides (Aβ). Aβ binds to the …

Lifespan extension through pharmacological intervention may provide valuable tools to
understanding the mechanisms of aging and could uncover new therapeutic approaches for the …